Association between oral microbial dysbiosis and poor functional outcomes in stroke-associated pneumonia patients.

ABSTRACT:

Background

Despite advances in our understanding of the critical role of the microbiota in stroke patients, the oral microbiome has rarely been reported to be associated with stroke-associated pneumonia (SAP). We sought to profile the oral microbial composition of SAP patients and to determine whether microbiome temporal instability and special taxa are associated with pneumonia progression and functional outcomes.

Methods

This is a prospective, observational, single-center cohort study that examined patients with acute ischemic stroke (AIS) who were admitted within 24 h of experiencing a stroke event. The patients were divided into three groups based on the occurrence of pneumonia and the use of mechanical ventilation: nonpneumonia group, SAP group, and ventilator-associate

SUBMITTER: Ren Y 

PROVIDER: S-EPMC10594709 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature