Colonic distribution of FMT by different enema procedures compared to colonoscopy - proof of concept study using contrast fluid.

ABSTRACT:

Background

Fecal microbiota transplantation (FMT) has become an important treatment method in recurrent Clostridioides difficile infections and is under investigation as a treatment for several other diseases. FMT's mechanism of action is assumed to be through alterations of the colon microbiota. FMT can be delivered by several methods, but few studies have directly compared how FMT is distributed in the colon by different methods. Specifically, the proximal distribution of FMT delivered by enema is unknown.

Methods

In eight participants, we administered contrast fluid (CF) with viscosity similar to an FMT in a crossover study design. First, CF was administered by colonoscopy, followed by an abdominal X-ray to visualize the CF distribution. Next, after four to eight weeks, p

SUBMITTER: Skjevling LK 

PROVIDER: S-EPMC10594821 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature