Statistical Analysis and Tokenization of Epitopes to Construct Artificial Neoepitope Libraries.

ABSTRACT: Epitopes are specific regions on an antigen's surface that the immune system recognizes. Epitopes are usually protein regions on foreign immune-stimulating entities such as viruses and bacteria, and in some cases, endogenous proteins may act as antigens. Identifying epitopes is crucial for accelerating the development of vaccines and immunotherapies. However, mapping epitopes in pathogen proteomes is challenging using conventional methods. Screening artificial neoepitope libraries against antibodies can overcome this issue. Here, we applied conventional sequence analysis and methods inspired in natural language processing to reveal specific sequence patterns in the linear epitopes deposited in the Immune Epitope Database (www.iedb.org) that can serve as building blocks for the design of un

SUBMITTER: Lopez-Martinez E 

PROVIDER: S-EPMC10594869 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature