An experimental study on lung deposition of inhaled 2 μm particles in relation to lung characteristics and deposition models.

ABSTRACT:

Background

The understanding of inhaled particle respiratory tract deposition is a key link to understand the health effects of particles or the efficiency for medical drug delivery via the lung. However, there are few experimental data on particle respiratory tract deposition, and the existing data deviates considerably when comparing results for particles > 1 μm.

Methods

We designed an experimental set-up to measure deposition in the respiratory tract for particles > 1 μm, more specifically 2.3 μm, with careful consideration to minimise foreseen errors. We measured the deposition in seventeen healthy adults (21-68 years). The measurements were performed at tidal breathing, during three consecutive 5-minute periods while logging breathing patterns. Pulmonary function tests

SUBMITTER: Rissler J 

PROVIDER: S-EPMC10594870 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature