The association between basal metabolic rate and osteoarthritis: a Mendelian randomization study.

ABSTRACT:

Background

The role of the basal metabolic rate (BMR) in osteoarthritis (OA) remains unclear, as previous retrospective studies have produced inconsistent results. Therefore, we performed a Mendelian randomization (MR) study to systematically investigate the causal relationship between the BMR and OA.

Methods

Single-nucleotide polymorphism (SNP) data related to BMR and OA were collected in a genome-wide association study. Using OA as the outcome variable and BMR as the exposure factor, SNPs with strong correlation with the BMR as the tool variable were screened. The correlation between the BMR and OA risk was evaluated using the inverse-variance weighted method, and heterogeneity and pleiotropy were evaluated using a sensitivity analysis.

Results

There was a potential

SUBMITTER: Zhou J 

PROVIDER: S-EPMC10594886 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature