Impact of worst pattern of invasion on prognosis of oral squamous cell carcinoma: a systematic review and meta-analysis.

ABSTRACT:

Objective

The relationship between the worst pattern of invasion (WPOI) and the prognosis of oral squamous cell carcinoma (OSCC) remains controversial. This systematic review and meta-analysis was performed to determine the impact of the WPOI on the prognosis of OSCC.

Methods

Studies from six databases were assessed for quality using the Newcastle-Ottawa Scale, and data were analyzed using Stata software.

Results

Eighteen studies involving 3954 patients showed that patients with a WPOI of 4 to 5 had significantly worse overall survival, disease-specific survival, and disease-free survival than patients with a WPOI of 1 to 3. Significant associations of the WPOI with locoregional recurrence and mortality were found.

Conclusion

A higher WPOI was significantly ass

SUBMITTER: Binmadi NO 

PROVIDER: S-EPMC10594968 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature