Aldehyde dehydrogenase 2 gene rs671 G>A polymorphism is associated with an increased risk of digestive tract cancer.

ABSTRACT:

Objective

Acetaldehyde can accumulate in cells and form acetaldehyde-DNA adducts that result in digestive tract cancer development. Acetaldehyde dehydrogenase 2 (ALDH2) enzymatic activity is involved in this process. Here, we aimed to analyze the relationship between an ALDH2 gene polymorphism and the digestive tract cancer risk in the Hakka population in China.

Methods

This was a retrospective study, with the ALDH2 rs671 genotype and medical record information collected from all subjects. The relationships between these factors, including various blood cell parameters, and digestive tract cancer susceptibility were analyzed.

Results

Overall, 307 cancer patients and 317 controls were included. The cancer patients had significantly higher percentages with

SUBMITTER: Yang Y 

PROVIDER: S-EPMC10594971 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature