Volatile profiling distinguishes <i>Streptococcus pyogenes</i> from other respiratory streptococcal species.

ABSTRACT: Sore throat is one of the most common complaints encountered in the ambulatory clinical setting. Rapid, culture-independent diagnostic techniques that do not rely on pharyngeal swabs would be highly valuable as a point-of-care strategy to guide outpatient antibiotic treatment. Despite the promise of this approach, efforts to detect volatiles during oropharyngeal infection have yet been limited. In our research study, we sought to evaluate for specific bacterial volatile organic compounds (VOC) biomarkers in isolated cultures in vitro, in order to establish proof-of-concept prior to initial clinical studies of breath biomarkers. A particular challenge for the diagnosis of pharyngitis due to Streptococcus pyogenes is the likelihood that many metabolites may be shared by S. p

SUBMITTER: Berna AZ 

PROVIDER: S-EPMC10597408 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature