Eggs of the mosquito Aedes aegypti survive desiccation by rewiring their polyamine and lipid metabolism.

ABSTRACT: Upon water loss, some organisms pause their life cycles and escape death. While widespread in microbes, this is less common in animals. Aedes mosquitoes are vectors for viral diseases. Aedes eggs can survive dry environments, but molecular and cellular principles enabling egg survival through desiccation remain unknown. In this report, we find that Aedes aegypti eggs, in contrast to Anopheles stephensi, survive desiccation by acquiring desiccation tolerance at a late developmental stage. We uncover unique proteome and metabolic state changes in Aedes embryos during desiccation that reflect reduced central carbon metabolism, rewiring towards polyamine production, and enhanced lipid utilisation for energy and polyamine synthesis. Using inhibitors targeting these processes in blood-fed mosqui

SUBMITTER: Prasad A 

PROVIDER: S-EPMC10597479 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature