Dual-color core-shell silica nanosystems for advanced super-resolution biomedical imaging.

ABSTRACT: Fluorescent core-shell silica nanoparticles are largely employed in nanomedicine and life science thanks to the many advantages they offer. Among these, the enhancement of the stability of the fluorescent signal upon fluorophore encapsulation into the silica matrix and the possibility to combine in a single vehicle multiple functionalities, physically separated in different compartments. In this work, we present a new approach to the Stöber method as a two-cycle protocol for the tailored synthesis of dual-color fluorescent core-shell silicon dioxide nanoparticles (SiO₂ NPs) using two commercial dyes as model. To facilitate the colloidal stability, the nanoparticle surface was functionalized with biotin by two approaches. The biotinylated nanosystems were characterized by several

SUBMITTER: Ramirez-Morales MA 

PROVIDER: S-EPMC10597559 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature