Skeletal Muscle Transcriptome Alterations Related to Declining Physical Function in Older Mice.

ABSTRACT: One inevitable consequence of aging is the gradual deterioration of physical function and exercise capacity, driven in part by the adverse effect of age on muscle tissue. We hypothesized that relationships exist between age-related differentially expressed genes (DEGs) in skeletal muscle and age-associated declines in physical function and exercise capacity. Previously, male C57BL/6mice (6m, months old, 24m, and 28m) were tested for physical function using a composite scoring system (comprehensive functional assessment battery, CFAB) comprised of five well-validated tests of physical function. In this study, total RNA was isolated from tibialis anterior samples (n = 8) randomly selected from each age group in the parent study. Using Next Generation Sequencing RNAseq to determine DEGs durin

SUBMITTER: Graber TG 

PROVIDER: S-EPMC10597580 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature