Identifying patient-related predictors of permanent growth hormone deficiency.

ABSTRACT:

Objective

Isolated childhood growth hormone deficiency (GHD) can persist into adulthood, and re-testing at the transition period is needed to determine whether continued growth hormone therapy is indicated. Here, our objective was to identify predictors of permanent GHD.

Design

Retrospective single-centre study of patients with childhood-onset GHD who were re-tested after adult height attainment.

Methods

Auxological, clinical, laboratory, and MRI data throughout follow-up were collected.

Results

We included 101 patients. At GH treatment initiation, age was 8.1 ± 0.4 years, height -2.25 ± 0.8, and BMI -0.27 ± 0.1 SDS. The 29 (28.7%) patients with persistent GHD had lower height SDS (-2.57 ± 0.1 vs. -2.11 ± 0.1, p<0.001) and mean GH peaks (8.4 ± 1.0 vs.13.

SUBMITTER: Mericq V 

PROVIDER: S-EPMC10597646 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature