The causality between obstructive sleep apnea and ventricular structure and function: a bidirectional Mendelian randomization study.

ABSTRACT: Background: Multiple observational studies have discovered a substantial link between obstructive sleep apnea (OSA) and ventricular dysfunction. However, conventional observational studies are vulnerable to causal reversal and confounding, making it challenging to infer the causes of effects and their direction. Methods: With the help of a bidirectional, two-sample Mendelian randomization (MR) study, we assessed the potential causality between OSA and left and right ventricular (LV, RV) structure and function. We conducted our analysis utilizing summary data from genome-wide association studies of OSA (16,761 cases and 201,194 controls) in the FinnGen Study, as well as LV (36,041 participants) and RV (29,506 participants) in the UK Biobank cardiovascular magnetic resonance re

SUBMITTER: Sun W 

PROVIDER: S-EPMC10597648 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature