Long-term blood pressure patterns in midlife and dementia in later life: Findings from the Framingham Heart Study.

ABSTRACT:

Introduction

Long-term blood pressure (BP) measures, such as visit-to-visit BP variability (BPV) and cumulative BP, are strong indicators of cardiovascular risks. This study modeled up to 20 years of BP patterns representative of midlife by using BPV and cumulative BP, then examined their associations with development of dementia in later life.

Methods

For 3201 individuals from the Framingham Heart Study, multivariate logistic regression analyses were performed to examine the association between long-term BP patterns during midlife and the development of dementia (ages ≥ 65).

Results

After adjusting for covariates, every quartile increase in midlife cumulative BP was associated with a sequential increase in the risk of developing dementia (e.g., highest quartile of cu

SUBMITTER: Kim H 

PROVIDER: S-EPMC10597747 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature