Dataset Information

Humanistic and Economic Burden of Patients with Cardiorenal Metabolic Conditions: A Systematic Review.

ABSTRACT:

Introduction

Diabetes is associated with significant economic burden. Moreover, cardiovascular disease (CVD), including heart failure, and chronic kidney disease (CKD) are common comorbidities, leading to premature mortality. We conducted a systematic review to assess the humanistic and economic burden of cardio-renal-metabolic (CRM) conditions in individuals ≥ 18 years with CVD, CKD, and type 2 diabetes mellitus.

Methods

We searched Embase^® and Medline^® databases from 2011 to January 10, 2022 for English publications reporting humanistic and economic burden outcomes from observational studies, real-world evidence, and economic model studies. Intervention and validation studies were excluded. Study quality was assessed using the Newcastle-Ottawa Scale. Abstracts/posters were identified from four conferences (2020-2022).

Results

Of 1804 studies identified, 22 (including four conference publications) were selected involving 351,296,930 participants (one modeled the US population); eight reported healthcare resource utilization (HCRU), seven only cost data, six HCRU and cost data, one reported quality-of-life data (11/18 and 7/18 had estimated low and medium risk of bias, respectively). Participants were predominantly ≥ 65 years and identified as having White ethnicity. Higher costs and HCRU were observed in patients with all three conditions compared to those with two or none. Urban/metropolitan and insured patients had higher healthcare expenditure and service utilization compared to uninsured and racial/ethnic minority populations. Comorbidities were associated with increased hospitalizations, higher costs, and more emergency department visits. In general, patients identified as having Black ethnicity had low odds of using healthcare services, possibly due to disparities in healthcare access and distrust in the system. Limitations included no adjustment for inflation and a predominance of retrospective studies.

Conclusions

This review showed a greater economic burden for patients with CRM conditions, with a clear trend between increasing numbers of comorbidities and increasing healthcare costs/resource use. Comparisons between countries are complicated and the scarcity of evidence from minority racial and ethnic groups and lack of data from non-US geographies warrant further investigation.

SUBMITTER: Ferdinand KC

PROVIDER: S-EPMC10597898 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature

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Publications

Humanistic and Economic Burden of Patients with Cardiorenal Metabolic Conditions: A Systematic Review.

Ferdinand Keith C KC Norris Keith C KC Rodbard Helena W HW Trujillo Jennifer M JM

Diabetes therapy : research, treatment and education of diabetes and related disorders 20230926 12

<h4>Introduction</h4>Diabetes is associated with significant economic burden. Moreover, cardiovascular disease (CVD), including heart failure, and chronic kidney disease (CKD) are common comorbidities, leading to premature mortality. We conducted a systematic review to assess the humanistic and economic burden of cardio-renal-metabolic (CRM) conditions in individuals ≥ 18 years with CVD, CKD, and type 2 diabetes mellitus.<h4>Methods</h4>We searched Embase<sup>®</sup> and Medline<sup>®</sup> data ...[more]

PMID: 37751142

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Dataset Information

Humanistic and Economic Burden of Patients with Cardiorenal Metabolic Conditions: A Systematic Review.

Introduction

Methods

Results

Conclusions

Publications

Humanistic and Economic Burden of Patients with Cardiorenal Metabolic Conditions: A Systematic Review.

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