Biocatalytic Buoyancy-Driven Nanobots for Autonomous Cell Recognition and Enrichment.

ABSTRACT: Autonomously self-propelled nanoswimmers represent the next-generation nano-devices for bio- and environmental technology. However, current nanoswimmers generate limited energy output and can only move in short distances and duration, thus are struggling to be applied in practical challenges, such as living cell transportation. Here, we describe the construction of biodegradable metal-organic framework based nanobots with chemically driven buoyancy to achieve highly efficient, long-distance, directional vertical motion to "find-and-fetch" target cells. Nanobots surface-functionalized with antibodies against the cell surface marker carcinoembryonic antigen are exploited to impart the nanobots with specific cell targeting capacity to recognize and separate cancer cells. We demonstrate that t

SUBMITTER: Guo Z 

PROVIDER: S-EPMC10597912 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature