Control of CD4⁺ T cells to restrain inflammatory diseases via eukaryotic elongation factor 2 kinase.

ABSTRACT: CD4⁺ T cells, particularly IL-17-secreting helper CD4⁺ T cells, play a central role in the inflammatory processes underlying autoimmune disorders. Eukaryotic Elongation Factor 2 Kinase (eEF2K) is pivotal in CD8⁺ T cells and has important implications in vascular dysfunction and inflammation-related diseases such as hypertension. However, its specific immunological role in CD4⁺ T cell activities and related inflammatory diseases remains elusive. Our investigation has uncovered that the deficiency of eEF2K disrupts the survival and proliferation of CD4⁺ T cells, impairs their ability to secrete cytokines. Notably, this dysregulation leads to heightened production of pro-inflammatory cytokine IL-17, fosters a pro-inflammatory microenviron

SUBMITTER: Peng HY 

PROVIDER: S-EPMC10598003 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature