Enhanced brain structure-function tethering in transmodal cortex revealed by high-frequency eigenmodes.

ABSTRACT: While the link between brain structure and function remains an ongoing challenge, the prevailing hypothesis is that the structure-function relationship may itself be gradually decoupling from unimodal to transmodal cortex. However, this hypothesis is constrained by the underlying models which may neglect requisite information. Here we relate structural and functional connectivity derived from diffusion and functional MRI through orthogonal eigenmodes governing frequency-specific diffusion patterns. We find that low-frequency eigenmodes contribute little to functional interactions in transmodal cortex, resulting in divergent structure-function relationships. Conversely, high-frequency eigenmodes predominantly support neuronal coactivation patterns in these areas, inducing structure-function

SUBMITTER: Yang Y 

PROVIDER: S-EPMC10598018 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature