Diffusion-weighted imaging complements T2-weighted MRI for tumour response assessment in squamous anal carcinoma.

ABSTRACT:

Objectives

A published tumour regression grade (TRG) score for squamous anal carcinoma treated with definitive chemoradiotherapy based on T2-weighted MRI yields a high proportion of indeterminate responses (TRG-3). We investigate whether the addition of diffusion-weighted imaging (DWI) improves tumour response assessment in the early post treatment period.

Materials and methods

This retrospective observational study included squamous anal carcinoma patients undergoing MRI before and within 3 months of completing chemoradiotherapy from 2009 to 2020. Four independent radiologists (1-20 years' experience) scored MRI studies using a 5-point TRG system (1 = complete response; 5 = no response) based on T2-weighted sequences alone, and then after a 12-week washout period, using a 5

SUBMITTER: Prezzi D 

PROVIDER: S-EPMC10598114 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature