Production of marmoset eggs and embryos from xenotransplanted ovary tissues.

ABSTRACT: The common marmoset (Callithrix jacchus) has attracted attention as a valuable primate model for the analysis of human diseases. Despite the potential for primate genetic modification, however, its widespread lab usage has been limited due to the requirement for a large number of eggs. To make up for traditional oocyte retrieval methods such as hormone administration and surgical techniques, we carried out an alternative approach by utilizing ovarian tissue from deceased marmosets that had been disposed of. This ovarian tissue contains oocytes and can be used as a valuable source of follicles and oocytes. In this approach, the ovarian tissue sections were transplanted under the renal capsules of immunodeficient mice first. Subsequent steps consist of development of follicles by hormone adm

SUBMITTER: Hirayama R 

PROVIDER: S-EPMC10598121 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature