Bone Turnover in Patients with Chronic Kidney Disease Stage 5D and Healthy Controls - a Quantitative [¹⁸F]Fluoride PET Study.

ABSTRACT:

Background

Chronic kidney disease (CKD) is prevalent in the aging population and increases the risk of fracture 2-4 times. We compared optimized quantitative [¹⁸F]fluoride PET/CT methods to the reference standard with arterial input function (AIF) to identify a clinically accessible method for evaluation of bone turnover in patients with CKD.

Methods

Ten patients on chronic hemodialysis treatment and ten control patients were recruited. A dynamic 60-min [¹⁸F]fluoride PET scan was obtained from the 5th lumbar vertebra to the proximal femur simultaneously with arterial blood sampling to achieve an AIF. Individual AIFs were time-shifted to compute a population curve (PDIF). Bone and vascular volumes-of-interest (VOIs) were drawn, and an image-derived-input

SUBMITTER: Fuglo D 

PROVIDER: S-EPMC10598153 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature