Transthyretin promotes the invasion of combined hepatocellular cholangiocarcinoma by tumor-associated macrophages.

ABSTRACT:

Background

Patients with combined hepatocellular-cholangiocarcinoma (cHCC-CCA) have limited treatment options and poor prognosis. Tumor-associated macrophages (TAMs) are the most abundant infiltrating immune cells in the tumor microenvironment and promote tumor stemness, proliferation, invasion and metastasis. Evidence suggested that transthyretin (TTR) influenced the prolifetation and invasion functions of different tumors and play an essential role in the tumor microenvironment.

Aims

To investigate the involvement of TTR in TAMs affecting the invasion of cHCC-CCA.

Methods and results

Data sets obtained from the Gene Expression Omnibus database were integrated. Differentially expressed genes (DEGs) were obtained using R software, and modules associated with cHCC-CCA

SUBMITTER: Ke K 

PROVIDER: S-EPMC10598247 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature