MiR-100 rs1834306 a > G polymorphism decreases neuroblastoma risk in Chinese children.

ABSTRACT:

Background

Neuroblastoma is a common malignant tumor stemming from the sympathetic nervous system in children, which is often life-threatening. The genetics of neuroblastoma remains unclear. Studies have shown that miRNAs participate in the regulation of a broad spectrum of biological pathways. The abnormity in the miRNA is associated with the risk of various cancers, including neuroblastoma. However, research on the relationship of miRNA polymorphisms with neuroblastoma susceptibility is still in the initial stage.

Methods

In this research, a retrospective case-control study was conducted to explore whether miR-100 rs1834306 A > G polymorphism is associated with neuroblastoma susceptibility. We enrolled 402 cases and 473 controls for the study. The logistic regression analy

SUBMITTER: Han Y 

PROVIDER: S-EPMC10598254 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature