TAZ upregulates MIR-224 to inhibit oxidative stress response in multiple myeloma.

ABSTRACT:

Background

Oxidative stress within the bone marrow niche of multiple myeloma contributes to disease progression and drug resistance. Recent studies have associated the Hippo pathway with miRNA biogenesis and oxidative stress in solid tumors. Oxidative stress and miRNA pathway inter-relates in several cancers. Our group recently showed that TAZ functions as a tumor suppressor in MM. However, the role of TAZ in oxidative stress in MM is unknown.

Aims

We sought to examine the role of TAZ in myeloma cells' response to BM oxidative stress. We postulated that TAZ might be associated with an oxidative stress phenotype and distinct miRNA signature in MM.

Methods and results

Using human myeloma cell lines and clinical samples, we demonstrate that TAZ promotes myeloma cells' se

SUBMITTER: Abegunde SO 

PROVIDER: S-EPMC10598259 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature