Disrupted brain mitochondrial morphology after in vivo hydrogen sulfide exposure.

ABSTRACT: Changes in mitochondrial dynamics are often associated with dietary patterns, medical treatments, xenobiotics, and diseases. Toxic exposures to hydrogen sulfide (H₂S) harm mitochondria by inhibiting Complex IV and via other mechanisms. However, changes in mitochondrial dynamics, including morphology following acute exposure to H₂S, are not yet fully understood. This study followed mitochondrial morphology changes over time after a single acute LCt₅₀ dose of H₂S by examining electron microscopy thalami images of surviving mice. Our findings revealed that within the initial 48 h after H₂S exposure, mitochondrial morphology was impaired by H₂S, supported by the disruption and scarcity of the cristae, which are required to enhan

SUBMITTER: Rumbeiha WK 

PROVIDER: S-EPMC10598273 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature