Assessment of long-term graft function following total pancreatectomy and autologous islet transplantation: the Leicester experience.

ABSTRACT:

Background

Total pancreatectomy and islet autotransplantation (TPIAT) is a recognised treatment for chronic pancreatitis (CP) with the potential to mitigate or prevent pancreatogenic diabetes. We present our 10-year follow-up of TPIAT patients.

Methods

The University Hospitals of Leicester performed 60 TPIAT procedures from September 1994 to May 2011. Seventeen patients completed their 10-year assessment and were grouped using the modified Auto-Igls criteria; good response, n=5 (insulin-independent for first 5 years post-TPIAT); partial response, n=6 (insulin requirements <20 iU/day post-TPIAT) and poor response, n=6 (insulin requirements ≥20 iU/day post-TPIAT). C-peptide, haemoglobin A1c (HbA_1c) and oral glucose tolerance test (OGTT) were undertaken preoperativel

SUBMITTER: Pollard CA 

PROVIDER: S-EPMC10598318 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature