Dysregulated metal ion homeostasis underscores non-canonical function of CD8⁺ T cell during COVID-19.

ABSTRACT:

Introduction

Several efforts have been made to describe the complexity of T cell heterogeneity during the COVID-19 disease; however, there remain gaps in our understanding in terms of the granularity within.

Methods

For this attempt, we performed a single-cell transcriptomic analysis of 33 individuals (4 healthy, 16 COVID-19 positive patients, and 13 COVID-19 recovered individuals).

Results

We found CD8⁺ T cell-biased lymphopenia in COVID-19 patients compared to healthy and recovered individuals. We also found an optimal Th1/Th2 ratio, indicating an effective immune response during COVID-19. Expansion of activated CD4⁺ T and NK T was detected in the COVID-19-positive individuals. Surprisingly, we found cellular and metal ion homeostasis pathways

SUBMITTER: Khare K 

PROVIDER: S-EPMC10598344 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature