Learning the kernel for rare variant genetic association test.

ABSTRACT: Introduction: Compared to Genome-Wide Association Studies (GWAS) for common variants, single-marker association analysis for rare variants is underpowered. Set-based association analyses for rare variants are powerful tools that capture some of the missing heritability in trait association studies. Methods: We extend the convex-optimized SKAT (cSKAT) test set procedure which learns from data the optimal convex combination of kernels, to the full Generalised Linear Model (GLM) setting with arbitrary non-genetic covariates. We call this extended cSKAT (ecSKAT) and show that the resulting optimization problem is a quadratic programming problem that can be solved with no additional cost compared to cSKAT. Results: We show that a modified objective is related to an upper bo

SUBMITTER: Falk I 

PROVIDER: S-EPMC10598548 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature