MiR-431 secreted by human vestibular schwannomas increases the mammalian inner ear's vulnerability to noise trauma.

ABSTRACT:

Introduction

Vestibular schwannoma (VS) is an intracranial tumor that arises on the vestibular branch of cranial nerve VIII and typically presents with sensorineural hearing loss (SNHL). The mechanisms of this SNHL are postulated to involve alterations in the inner ear's microenvironment mediated by the genetic cargo of VS-secreted extracellular vesicles (EVs). We aimed to identify the EV cargo associated with poor hearing and determine whether its delivery caused hearing loss and cochlear damage in a mouse model in vivo.

Methods

VS tissue was collected from routinely resected tumors of patients with good (VS-GH) or poor (VS-PH) pre-surgical hearing measured via pure-tone average and word recognition scores. Next-generation sequencing was performed on RNA isolated fro

SUBMITTER: Fujita T 

PROVIDER: S-EPMC10598552 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature