SHIP: identifying antimicrobial resistance gene transfer between plasmids.

ABSTRACT:

Motivation

Plasmids are carriers for antimicrobial resistance (AMR) genes and can exchange genetic material with other structures, contributing to the spread of AMR. There is no reliable approach to identify the transfer of AMR genes across plasmids. This is mainly due to the absence of a method to assess the phylogenetic distance of plasmids, as they show large DNA sequence variability. Identifying and quantifying such transfer can provide novel insight into the role of small mobile elements and resistant plasmid regions in the spread of AMR.

Results

We developed SHIP, a novel method to quantify plasmid similarity based on the dynamics of plasmid evolution. This allowed us to find conserved fragments containing AMR genes in structurally different and phylogenetically distan

SUBMITTER: Teixeira M 

PROVIDER: S-EPMC10598575 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature