Tanshinone IIA alleviates atherosclerosis in LDLR^-/- mice by regulating efferocytosis of macrophages.

ABSTRACT: Background: Tanshinone IIA (TIIA) is the major lipid-soluble active ingredient of the traditional Chinese medicine Salvia miltiorrhiza, which slows down atherosclerosis (AS). However, it remains unclear whether TIIA has the potential to enhance macrophage efferocytosis and thereby improve atherosclerosis. Objective: The focus of this examination was to determine if TIIA could reduce lipid accumulation and treat AS by enhancing efferocytosis. Methods: Firstly, we conducted in vivo experiments using LDLR knockout (LDLR^-/-) mice for a period of 24 weeks, using histopathological staining, immunofluorescence and Western blot experiments to validate from the efficacy and mechanism parts, respectively; in addition, we utilized cells to validate our st

SUBMITTER: Wang J 

PROVIDER: S-EPMC10598641 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature