VariantSurvival: a tool to identify genotype-treatment response.

ABSTRACT: Motivation: For a number of neurological diseases, such as Alzheimer's disease, amyotrophic lateral sclerosis, and many others, certain genes are known to be involved in the disease mechanism. A common question is whether a structural variant in any such gene may be related to drug response in clinical trials and how this relationship can contribute to the lifecycle of drug development. Results: To this end, we introduce VariantSurvival, a tool that identifies changes in survival relative to structural variants within target genes. VariantSurvival matches annotated structural variants with genes that are clinically relevant to neurological diseases. A Cox regression model determines the change in survival between the placebo and clinical trial groups with respect to the numbe

SUBMITTER: Krannich T 

PROVIDER: S-EPMC10598652 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature