The first case report of complement component 7 deficiency in Qatar and a 10-year follow-up.

ABSTRACT:

Introduction

Neisseria meningitidis is a significant cause of bacterial meningitis and septicemia worldwide. Recurrent Neisseria meningitidis is frequently associated with terminal complement protein deficiency, including Complement component 7. This report discusses the first case of C7 deficiency in Qatar.

Case report

A 30-year-old Qatari man presented with a meningococcal infection, which was verified by a blood culture. He experienced two episodes of meningitis caused by an undetermined organism. His blood tests revealed low levels of CH50 and C7. His C7 gene testing revealed a homozygous mutation in exon 10 (c.1135G>C p.Gly379Arg), a mutation that has not been previously documented in Qatar. However, it has been observed in 1% of Moroccan-origin Israeli Je

SUBMITTER: Khalil SM 

PROVIDER: S-EPMC10598862 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature