Synthesis of Two-Dimensional (Cu-S)_n Metal-Organic Framework Nanosheets Applied as Peroxidase Mimics for Detection of Glutathione.

ABSTRACT: Facilely synthesized peroxidase-like nanozymes with high catalytic activity and stability may serve as effective biocatalysts. The present study synthesizes peroxidase-like nanozymes with multinuclear active sites using two-dimensional (2D) metal-organic framework (MOF) nanosheets and evaluates them for their practical applications. A simple method involving a one-pot bottom-up reflux reaction is developed for the mass synthesis of (Cu-S)_n MOF 2D nanosheets, significantly increasing production quantity and reducing reaction time compared to traditional autoclave methods. The (Cu-S)_n MOF 2D nanosheets with the unique coordination of Cu(I) stabilized in Cu-based MOFs demonstrate impressive activity in mimicking natural peroxidase. The active sites of the p

SUBMITTER: Yu YH 

PROVIDER: S-EPMC10598880 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature