Trajectory patterns of metabolic syndrome severity score and risk of type 2 diabetes.

ABSTRACT:

Background

The available evidence indicates that the severity of metabolic syndrome tends to worsen progressively over time. We assessed the trajectory of age and sex-specific continuous MetS severity score (cMetS-S) and its association with the development of diabetes during an 18-year follow-up.

Methods

In a prospective population-based Tehran Lipid and Glucose Study, 3931 eligible participants free of diabetes, aged 20-60 years, were followed at three-year intervals. We examined the trajectories of cMetS-S over nine years using latent growth mixture modeling (LGMM) and subsequent risks of incident diabetes eight years later. The prospective association of identified trajectories with diabetes was examined using the Cox proportional hazard model adjusting for age, sex, edu

SUBMITTER: Amouzegar A 

PROVIDER: S-EPMC10598905 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature