Global-scale GWAS associates a subset of SNPs with animal-adapted variants in M. tuberculosis complex.

ABSTRACT:

Background

While Mycobacterium tuberculosis complex (MTBC) variants are clonal, variant tuberculosis is a human-adapted pathogen, and variant bovis infects many hosts. Despite nucleotide identity between MTBC variants exceeding 99.95%, it remains unclear what drives these differences. Markers of adaptation into variants were sought by bacterial genome-wide association study of single nucleotide polymorphisms extracted from 6,362 MTBC members from varied hosts and countries.

Results

The search identified 120 genetic loci associated with MTBC variant classification and certain hosts. In many cases, these changes are uniformly fixed in certain variants while absent in others in this dataset, providing good discriminatory power in distinguishing variants by polymorphisms. Multip

SUBMITTER: Brenner EP 

PROVIDER: S-EPMC10598944 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature