Alterations in pathogen-specific cellular and humoral immunity associated with acute peripheral facial palsy of infectious origin.

ABSTRACT:

Background

Peripheral facial palsy (PFP) is a common neurologic symptom which can be triggered by pathogens, autoimmunity, trauma, tumors, cholesteatoma or further local conditions disturbing the peripheral section of the nerve. In general, its cause is often difficult to identify, remaining unknown in over two thirds of cases. As we have previously shown that the quantity and quality of pathogen-specific T cells change during active infections, we hypothesized that such changes may also help to identify the causative pathogen in PFPs of unknown origin.

Methods

In this observational study, pathogen-specific T cells were quantified in blood samples of 55 patients with PFP and 23 healthy controls after stimulation with antigens from varicella-zoster virus (VZV), herpes-simplex

SUBMITTER: Mohammad L 

PROVIDER: S-EPMC10598953 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature