The inhibitory effect of Gremlin-2 on adipogenesis suppresses breast cancer cell growth and metastasis.

ABSTRACT:

Background

Gremlin-1 (GREM1) and Gremlin-2 (GREM2) are bone morphogenetic protein antagonists that play important roles in organogenesis, tissue differentiation, and tissue homeostasis. Although GREM1 has been reported to be involved in promoting various cancers, little has been reported about effects of GREM2 on cancer. Recently, it has been reported that GREM2 can inhibit adipogenesis in adipose-derived stromal/stem cells. However, as an inhibitor of adipogenesis, the role of GREM2 in cancer progression is not well understood yet.

Methods

Pre-adipocyte 3T3-L1 cells overexpressing mock or Grem2 were established using a lentiviral transduction system and differentiated into adipocytes-mock and adipocytes-Grem2, respectively. To investigate the effect of adipocyte-Grem2 on br

SUBMITTER: Jung J 

PROVIDER: S-EPMC10599028 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature