Characteristics of sodium and water retention in rats with nephrotic syndrome induced by puromycin aminonucleoside.

ABSTRACT:

Introduction

Nephrotic syndrome (NS) is characterized by renal sodium and water retention. The mechanisms are not fully elucidated.

Methods

The NS rat model was established by single intraperitoneal injection of 100 mg/kg puromycin aminonucleoside (PAN). The plasma electrolyte level and urinary sodium excretion were monitored dynamically. The changes of some sodium transporters, including epithelial Na⁺ channel (ENaC), Na⁺/H⁺ exchanger 3 (NHE3), Na⁺-K⁺-2Cl^- cotransporter 2 (NKCC2) and Na⁺-Cl^- cotransporter (NCC) in renal cortex at different time points and the level of peripheral circulation factors were detected.

Results

The urinary sodium excretion of the model group increased si

SUBMITTER: Xu Z 

PROVIDER: S-EPMC10599035 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature