Causal inference of sex hormone-binding globulin on venous thromboembolism: evidence from Mendelian randomisation.

ABSTRACT:

Background

Previous cohort studies have shown that exogenous sex hormone use, such as testosterone replacement therapy and oestrogen-containing contraceptives, can increase the risk of venous thromboembolism (VTE). However, the relationship between endogenous sex hormone levels and VTE remains unclear. The goal of the present study was to explore the causal roles of endogenous sex hormones, including hormone-binding globulin (SHBG), bioactive testosterone (BT), and total testosterone (TT), in VTE and its two subgroups, deep vein thrombosis (DVT) and pulmonary embolism (PE).

Methods

We used a genome-wide association study of sex hormones as exposure data and Finnish VTE data as the outcome. Inverse variance weighting, MR-Egger, and weighted median were used for two-sample Men

SUBMITTER: Wang S 

PROVIDER: S-EPMC10599068 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature