DNA-Dependent Interferon Induction and Lung Inflammation in <i>Bordetella pertussis</i> Infection.

ABSTRACT: Pertussis, caused by Bordetella pertussis, is a resurgent respiratory disease but the molecular mechanisms underlying pathogenesis are poorly understood. We recently showed the importance of type I and type III interferon (IFN) induction and signaling for the development of lung inflammation in B. pertussis-infected mouse models. Classically, these IFNs are induced by signaling through a variety of pattern recognition receptors (PRRs) on host cells. Here, we found that the PRR signaling adaptor molecules MyD88 and TRIF contribute to IFN induction and lung inflammatory pathology during B. pertussis infection. However, the PRRs Toll-like receptors (TLR) 3 and TLR4, which signal through TRIF and MyD88, respectively, played no role in IFN induction. Instead, the DNA-sensin

SUBMITTER: Ardanuy J 

PROVIDER: S-EPMC10599430 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature