Cooperative ligand binding to a double-stranded Ising lattice-Application to cofilin binding to actin filaments.

ABSTRACT: Cooperative ligand binding to linear polymers is fundamental in many scientific disciplines, particularly biological and chemical physics and engineering. Such ligand binding interactions have been widely modeled using infinite one-dimensional (1D) Ising models even in cases where the linear polymers are more complex (e.g. actin filaments and other double-stranded linear polymers). Here, we use sequence-generating and transfer matrix methods to obtain an analytical method for cooperative equilibrium ligand binding to double-stranded Ising lattices. We use this exact solution to evaluate binding properties and features and analyze experimental binding data of cooperative binding of the regulatory protein, cofilin, to actin filaments. This analysis, with additional experimental information a

SUBMITTER: Cao W 

PROVIDER: S-EPMC10599439 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature