Directing group assisted para-selective C-H alkynylation of unbiased arenes enabled by rhodium catalysis.

ABSTRACT: Regioselective C-H alkynylation of arenes via C-H activation is challenging yet a highly desirable transformation. In this regard, directing group assisted C(sp²)-H alkynylation of arenes offers a unique opportunity to ensure precise regioselectivity. While the existing methods are mainly centered around ortho-C-H alkynylation and a few for meta-C-H alkynylation, the DG-assisted para-selective C-H alkynylation is yet to be reported. Herein we disclose the first report on Rh-catalyzed para-C-H alkynylation of sterically and electronically unbiased arenes. The para-selectivity is achieved with the assistance of a cyano-based directing template and the selectivity remained unaltered irrespective of the steric and electronic influence of the

SUBMITTER: Dutta U 

PROVIDER: S-EPMC10599460 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature