Correlation of the methylomic signature of smoking during pregnancy with clinical traits in ADHD.

ABSTRACT:

Background

Attention deficit/hyperactivity disorder (ADHD) is a highly prevalent childhood disorder. Maternal smoking during pregnancy is a replicated environmental risk factor for this disorder. It is also a robust modifier of gene methylation during the prenatal developmental period. In this study, we sought to identify loci differentially methylated by maternal smoking during pregnancy and relate their methylation levels to various behavioural and physical outcomes relevant to ADHD.

Methods

We extracted DNA from blood samples from children diagnosed with ADHD and deeply phenotyped. Genome-wide DNA methylation was assessed using Infinium MethylationEPIC BeadChip. Maternal smoking during pregnancy was self-declared and assessed retrospectively.

Results

Our sample inc

SUBMITTER: Chaumette B 

PROVIDER: S-EPMC10599658 | biostudies-literature | 2023 Sep-Oct

REPOSITORIES: biostudies-literature