PD-L1-related IncRNAs are associated with malignant characteristics and immune microenvironment in glioma.

ABSTRACT:

Background

The expression of long non-coding RNA (lncRNA) can function as diagnostic and therapeutic biomarker for tumors. This research explores the role of PD-L1-related lncRNAs in affecting malignant characteristics and the immune microenvironment of glioma.

Methods

Downloading gene expression profiles and clinicopathological information of glioma from TCGA and CGGA databases, 6 PD-L1-related lncRNAs were identified through correlation analysis, Cox and LASSO regression analysis, establishing the risk score model based on them. Bioinformatics analysis and cell experiments in vitro were adopted to verify the effects of LINC01271 on glioma.

Results

Risk scores based on 6 PD-L1-related lncRNAs (AL355974.3, LINC01271, AC011899.3, MIR4500HG, LINC02594, AL357055.3

SUBMITTER: Xia Z 

PROVIDER: S-EPMC10599717 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature