Causal association between placental growth factor and coronary heart disease: a Mendelian randomization study.

ABSTRACT:

Objective

Placental growth factor (PlGF), an important polypeptide hormone, plays an important regulatory role in various physiological processes. Observational studies have shown that PlGF is associated with the risk of coronary heart disease (CHD). However, the causal association between PlGF and CHD is unclear at present. This study aimed to investigate the causal association between genetically predicted PlGF levels and CHD.

Methods

Single nucleotide polymorphisms (SNPs) associated with PlGF were selected as instrumental variables (IVs) to evaluate the causal association between genetically predicted circulating PlGF levels and CHD risk by two-sample Mendelian randomization (MR).

Results

Inverse variance weighted (IVW) analysis showed that there was a suggestive c

SUBMITTER: Zuo B 

PROVIDER: S-EPMC10599727 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature