Senescence-associated inflammation and inhibition of adipogenesis in subcutaneous fat in Werner syndrome.

ABSTRACT: Werner syndrome (WS) is a hereditary premature aging disorder characterized by visceral fat accumulation and subcutaneous lipoatrophy, resulting in severe insulin resistance. However, its underlying mechanism remains unclear. In this study, we show that senescence-associated inflammation and suppressed adipogenesis play a role in subcutaneous adipose tissue reduction and dysfunction in WS. Clinical data from four Japanese patients with WS revealed significant associations between the decrease of areas of subcutaneous fat and increased insulin resistance measured by the glucose clamp. Adipose-derived stem cells from the stromal vascular fraction derived from WS subcutaneous adipose tissues (WSVF) showed early replicative senescence and a significant increase in the expression of senescence-

SUBMITTER: Sawada D 

PROVIDER: S-EPMC10599740 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature