Multi-omics analysis of MRPL-13 as a tumor-promoting marker from pan-cancer to lung adenocarcinoma.

ABSTRACT:

Background

As a member of the mitochondrial ribosomal protein family, mitochondrial ribosomal protein L13 (MRPL13) is responsible for synthesizing mitochondrial proteins in cells. Several studies have indicated that MRPL13 is associated with the proliferation cycle, migration ability, apoptosis and autophagy of cancer cells. However, a thorough examination of MRPL13 across cancers remains uncertain. Therefore, we tried to clarify the relationship between MRPL13 and pan-cancer, and verified it in lung adenocarcinoma by various methods. Finally, our research is expected to reveal new targets for pan-cancer treatment and improve the prognosis of cancer patients.

Methods

Using bioinformatics tools, we quantified the differential expression of MRPL13 between cancer tissues and co

SUBMITTER: Zhong X 

PROVIDER: S-EPMC10599762 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature