Early ascending growth is associated with maternal lipoprotein profile during mid and late pregnancy and in cord blood.

ABSTRACT:

Introduction

Intrauterine conditions and accelerating early growth are associated with childhood obesity. It is unknown, whether fetal programming affects the early growth and could alterations in the maternal-fetal metabolome be the mediating mechanism. Therefore, we aimed to assess the associations between maternal and cord blood metabolite profile and offspring early growth.

Methods

The RADIEL study recruited 724 women at high risk for gestational diabetes mellitus (GDM) BMI ≥ 30 kg/m² and/or prior GDM) before or in early pregnancy. Blood samples were collected once in each trimester, and from cord. Metabolomics were analyzed by targeted nuclear magnetic resonance (NMR) technique. Following up on offsprings' first 2 years growth, we discovered 3 distinct growth

SUBMITTER: Blanco Sequeiros E 

PROVIDER: S-EPMC10599999 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature