Mexican Biobank advances population and medical genomics of diverse ancestries.

ABSTRACT: Latin America continues to be severely underrepresented in genomics research, and fine-scale genetic histories and complex trait architectures remain hidden owing to insufficient data¹. To fill this gap, the Mexican Biobank project genotyped 6,057 individuals from 898 rural and urban localities across all 32 states in Mexico at a resolution of 1.8 million genome-wide markers with linked complex trait and disease information creating a valuable nationwide genotype-phenotype database. Here, using ancestry deconvolution and inference of identity-by-descent segments, we inferred ancestral population sizes across Mesoamerican regions over time, unravelling Indigenous, colonial and postcolonial demographic dynamics^2-6. We observed variation in runs of homozygosity among gen

SUBMITTER: Sohail M 

PROVIDER: S-EPMC10600006 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature